Titanium Coating of the Boston Keratoprosthesis
Identifieur interne : 000438 ( Main/Exploration ); précédent : 000437; suivant : 000439Titanium Coating of the Boston Keratoprosthesis
Auteurs : Borja Salvador-Culla [États-Unis] ; Kyung Jae Jeong [États-Unis] ; Paraskevi Evi Kolovou [États-Unis] ; Homer H. Chiang [États-Unis] ; James Chodosh [États-Unis] ; Claes H. Dohlman [États-Unis] ; Daniel S. Kohane [États-Unis]Source :
- Translational Vision Science & Technology [ 2164-2591 ] ; 2016.
Abstract
We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications.
Cylindrical rods were made of poly(methyl methacrylate) (PMMA), PMMA coated with titanium dioxide (TiO2) over a layer of polydopamine (PMMATiO2), smooth (Ti) and sandblasted (TiSB) titanium, and titanium treated with oxygen plasma (Tiox and TiSBox). Topography and surface chemistry were analyzed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Adhesion force between rods and porcine corneas was measured ex vivo. Titanium sleeves, smooth and sandblasted, were inserted around the stem of the B-KPro and implanted in rabbits. Tissue adhesion to the stem was assessed and compared to an unmodified B-Kpro after 1 month.
X-ray photoelectron spectroscopy demonstrated successful deposition of TiO2 on polydopamine-coated PMMA. Oxygen plasma treatment did not change the XPS spectra of titanium rods (Ti and TiSB), although it increased their hydrophilicity. The materials did not show cell toxicity. After 14 days of incubation, PMMATiO2, smooth titanium treated with oxygen plasma (Tiox), and sandblasted titanium rods (TiSB, TiSBox) showed significantly higher adhesion forces than PMMA ex vivo. In vivo, the use of a TiSB sleeve around the stem of the B-KPro induced a significant increase in tissue adhesion compared to a Ti sleeve or bare PMMA.
Sandblasted titanium sleeves greatly enhanced adherence of the B-KPro to the rabbit cornea. This approach may improve adhesion with the donor cornea in humans as well.
This approach may improve adhesion with donor corneas in humans.
Url:
DOI: 10.1167/tvst.5.2.17
PubMed: 27152247
PubMed Central: 4855478
Affiliations:
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Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. 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Chiang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chodosh, James" sort="Chodosh, James" uniqKey="Chodosh J" first="James" last="Chodosh">James Chodosh</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dohlman, Claes H" sort="Dohlman, Claes H" uniqKey="Dohlman C" first="Claes H." last="Dohlman">Claes H. Dohlman</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kohane, Daniel S" sort="Kohane, Daniel S" uniqKey="Kohane D" first="Daniel S." last="Kohane">Daniel S. Kohane</name><affiliation wicri:level="2"><nlm:aff id="aff2">Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27152247</idno><idno type="pmc">4855478</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855478</idno><idno type="RBID">PMC:4855478</idno><idno type="doi">10.1167/tvst.5.2.17</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000771</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000771</idno><idno type="wicri:Area/Pmc/Curation">000771</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000771</idno><idno type="wicri:Area/Pmc/Checkpoint">000390</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000390</idno><idno type="wicri:Area/Ncbi/Merge">006701</idno><idno type="wicri:Area/Ncbi/Curation">006701</idno><idno type="wicri:Area/Ncbi/Checkpoint">006701</idno><idno type="wicri:Area/Main/Merge">000438</idno><idno type="wicri:Area/Main/Curation">000438</idno><idno type="wicri:Area/Main/Exploration">000438</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Titanium Coating of the Boston Keratoprosthesis</title><author><name sortKey="Salvador Culla, Borja" sort="Salvador Culla, Borja" uniqKey="Salvador Culla B" first="Borja" last="Salvador-Culla">Borja Salvador-Culla</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2">Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jeong, Kyung Jae" sort="Jeong, Kyung Jae" uniqKey="Jeong K" first="Kyung Jae" last="Jeong">Kyung Jae Jeong</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Chemical Engineering, University of New Hampshire, Durham, NH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemical Engineering, University of New Hampshire, Durham, NH</wicri:regionArea><placeName><region type="state">New Hampshire</region></placeName></affiliation></author><author><name sortKey="Kolovou, Paraskevi Evi" sort="Kolovou, Paraskevi Evi" uniqKey="Kolovou P" first="Paraskevi Evi" last="Kolovou">Paraskevi Evi Kolovou</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chiang, Homer H" sort="Chiang, Homer H" uniqKey="Chiang H" first="Homer H." last="Chiang">Homer H. Chiang</name><affiliation wicri:level="2"><nlm:aff id="aff2">Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff3">David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chodosh, James" sort="Chodosh, James" uniqKey="Chodosh J" first="James" last="Chodosh">James Chodosh</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dohlman, Claes H" sort="Dohlman, Claes H" uniqKey="Dohlman C" first="Claes H." last="Dohlman">Claes H. Dohlman</name><affiliation wicri:level="2"><nlm:aff id="aff1">Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kohane, Daniel S" sort="Kohane, Daniel S" uniqKey="Kohane D" first="Daniel S." last="Kohane">Daniel S. Kohane</name><affiliation wicri:level="2"><nlm:aff id="aff2">Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Translational Vision Science & Technology</title><idno type="eISSN">2164-2591</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Purpose</title><p>We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications.</p></sec><sec id="st2"><title>Methods</title><p>Cylindrical rods were made of poly(methyl methacrylate) (PMMA), PMMA coated with titanium dioxide (TiO<sub>2</sub>) over a layer of polydopamine (PMMA<sub>TiO2</sub>), smooth (Ti) and sandblasted (Ti<sub>SB</sub>) titanium, and titanium treated with oxygen plasma (Ti<sub>ox</sub> and Ti<sub>SBox</sub>). Topography and surface chemistry were analyzed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). Adhesion force between rods and porcine corneas was measured ex vivo. Titanium sleeves, smooth and sandblasted, were inserted around the stem of the B-KPro and implanted in rabbits. Tissue adhesion to the stem was assessed and compared to an unmodified B-Kpro after 1 month.</p></sec><sec id="st3"><title>Results</title><p>X-ray photoelectron spectroscopy demonstrated successful deposition of TiO<sub>2</sub> on polydopamine-coated PMMA. Oxygen plasma treatment did not change the XPS spectra of titanium rods (Ti and Ti<sub>SB</sub>), although it increased their hydrophilicity. The materials did not show cell toxicity. After 14 days of incubation, PMMA<sub>TiO2</sub>, smooth titanium treated with oxygen plasma (Ti<sub>ox</sub>), and sandblasted titanium rods (Ti<sub>SB</sub>, Ti<sub>SBox</sub>) showed significantly higher adhesion forces than PMMA ex vivo. In vivo, the use of a Ti<sub>SB</sub> sleeve around the stem of the B-KPro induced a significant increase in tissue adhesion compared to a Ti sleeve or bare PMMA.</p></sec><sec id="st4"><title>Conclusions</title><p>Sandblasted titanium sleeves greatly enhanced adherence of the B-KPro to the rabbit cornea. This approach may improve adhesion with the donor cornea in humans as well.</p></sec><sec id="st5"><title>Translational Relevance</title><p>This approach may improve adhesion with donor corneas in humans.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dohlman, Ch" uniqKey="Dohlman C">CH, Dohlman</name></author><author><name sortKey="Schneider, Ha" uniqKey="Schneider H">HA, Schneider</name></author><author><name sortKey="Doane, Mg" uniqKey="Doane M">MG. Doane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Todani, A" uniqKey="Todani A">A, Todani</name></author><author><name sortKey="Ciolino, Jb" uniqKey="Ciolino J">JB, Ciolino</name></author><author><name sortKey="Ament, Jd" uniqKey="Ament J">JD, Ament</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doane, Mg" uniqKey="Doane M">MG, Doane</name></author><author><name sortKey="Dohlman, Ch" uniqKey="Dohlman C">CH, Dohlman</name></author><author><name sortKey="Bearse, G" uniqKey="Bearse G">G. Bearse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colby, Ka" uniqKey="Colby K">KA, Colby</name></author><author><name sortKey="Koo, Eb" uniqKey="Koo E">EB. 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Murphy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>New Hampshire</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Salvador Culla, Borja" sort="Salvador Culla, Borja" uniqKey="Salvador Culla B" first="Borja" last="Salvador-Culla">Borja Salvador-Culla</name></region><name sortKey="Chiang, Homer H" sort="Chiang, Homer H" uniqKey="Chiang H" first="Homer H." last="Chiang">Homer H. Chiang</name><name sortKey="Chiang, Homer H" sort="Chiang, Homer H" uniqKey="Chiang H" first="Homer H." last="Chiang">Homer H. Chiang</name><name sortKey="Chodosh, James" sort="Chodosh, James" uniqKey="Chodosh J" first="James" last="Chodosh">James Chodosh</name><name sortKey="Dohlman, Claes H" sort="Dohlman, Claes H" uniqKey="Dohlman C" first="Claes H." last="Dohlman">Claes H. Dohlman</name><name sortKey="Jeong, Kyung Jae" sort="Jeong, Kyung Jae" uniqKey="Jeong K" first="Kyung Jae" last="Jeong">Kyung Jae Jeong</name><name sortKey="Kohane, Daniel S" sort="Kohane, Daniel S" uniqKey="Kohane D" first="Daniel S." last="Kohane">Daniel S. Kohane</name><name sortKey="Kolovou, Paraskevi Evi" sort="Kolovou, Paraskevi Evi" uniqKey="Kolovou P" first="Paraskevi Evi" last="Kolovou">Paraskevi Evi Kolovou</name><name sortKey="Salvador Culla, Borja" sort="Salvador Culla, Borja" uniqKey="Salvador Culla B" first="Borja" last="Salvador-Culla">Borja Salvador-Culla</name><name sortKey="Salvador Culla, Borja" sort="Salvador Culla, Borja" uniqKey="Salvador Culla B" first="Borja" last="Salvador-Culla">Borja Salvador-Culla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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